Case Report on Obinutuzumab Treatment for Membranous Nephropathy After Rituximab Failure

829.4 KB PDF case report authored by Jianying Guo and published on figshare in April 2026. It details a 66-year-old woman with PLA2R-positive membranous nephropathy who developed anti-rituximab antibodies and treatment failure, then achieved remission with obinutuzumab.

Use Cases

• Analyze clinical outcomes of obinutuzumab as a rescue therapy based on the detailed patient timeline and remission data.
• Study the relationship between anti-rituximab antibodies, B-cell kinetics, and treatment failure based on the described immunological monitoring.
• Review therapeutic drug monitoring practices in refractory membranous nephropathy based on the reported serum rituximab and obinutuzumab levels.
• Examine histological confirmation of disease stage based on the kidney biopsy findings mentioned in the report.

Strengths

• 829.4 KB file size provides a detailed narrative of a single clinical case.
• Report includes specific clinical markers: anti-PLA2R antibody titers, serum drug levels, B-cell counts, and proteinuria measurements.
• Case timeline is clearly defined, with immunological and clinical remission achieved within 8.5 months of obinutuzumab treatment.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data reflects a single case report, limiting statistical generalizability.

Provenance

Source

figshare

Collection Method

Clinical case documentation and analysis.

Time Range

Covers the treatment timeline for a single patient case.

Freshness

Last updated 2026-04-13 05:20:42; freshness should be verified.

Geography

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