Paclitaxel-Eluting Silicone Airway Stent Design and In Vitro Performance

Supplementary file 1_Paclitaxel-eluting silicone airway stent with sustained drug release and potent anti-fibrotic activity.docx contains the full manuscript describing the development of a drug-eluting stent for benign central airway stenosis. The document details methods for hydrophilic modification, porous structure creation, and ultrasound-responsive drug release optimization, along with in vitro cytocompatibility and anti-fibrotic activity results. The work was authored by Mingmei Ding and last updated on 2026-05-12.

Use Cases

• Analyzing drug release kinetics based on the described pore-forming and ultrasound-enhancement coefficients.
• Evaluating material cytocompatibility based on the ISO 10993-5 criteria mentioned in the results.
• Comparing anti-fibrotic efficacy based on the selective inhibition of fibroblasts versus epithelial cells described.
• Studying the integration of hydrophilic modification and ultrasound activation for sustained local drug delivery.

Strengths

• The description provides specific quantitative results, such as 22.85% cumulative drug release over 90 days.
• The methodology is detailed, including the screening of three hydrophilic modifiers and systematic characterization of mechanical performance.
• The document is licensed under CC-BY-4.0, allowing for open sharing and reuse.

Limitations

• The dataset is a single 15.0 MB DOCX file; the underlying raw experimental data is not directly accessible in a structured format.
• Column-level documentation is absent; field semantics must be inferred from the manuscript text after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare

Collection Method

Research manuscript detailing experimental methods and results.

Freshness

Last updated 2026-05-12 05:42:36; freshness should be verified.