Immune Cell and Plasma Protein Data for Acute Gouty Arthritis

A multi-omics dataset from a study investigating immune remodeling in acute gouty arthritis. It includes mass cytometry (CyTOF) data from 56 patient PBMC samples, plasma proteomic data from 104 patients, and re-analyzed public single-cell RNA-seq data. The dataset was created by Peng Zhang and last updated on 2026-05-26.

Use Cases

• Identify immune cell phenotype associations with gout risk based on Mendelian randomization results.
• Analyze CD4+ naïve T cell transcriptional features and cell-cell communication networks from single-cell RNA-seq data.
• Validate plasma protein biomarkers like MMP1 and S100A12 for acute flare detection and recurrence risk stratification.

Strengths

• Integrates multiple data types: CyTOF immune profiling, single-cell RNA-seq, plasma proteomics, and Mendelian randomization.
• Includes data from defined patient cohorts: CyTOF analysis on 56 individuals and plasma proteomics on 104 individuals across training and validation sets.
• Results highlight specific biomarkers such as MMP1, which showed an exploratory AUC of 0.8533 for 12-week recurrence risk stratification.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to the source cohorts (European ancestry GWAS and Chinese patient cohorts).

Provenance

Source

figshare

Collection Method

Integrated analysis using bidirectional Mendelian randomization, CyTOF, single-cell RNA-seq re-analysis, and plasma proteomics (Olink platform).

Freshness

Last updated 2026-05-26 06:03:54; freshness should be verified.

Geography

Data derived from European ancestry GWAS datasets and patient cohorts from China.