Salvia Miltiorrhiza Effects on Osteoporosis in Animal Models: A Systematic Review

A systematic review and meta-analysis of 24 randomized controlled trials evaluating the pharmacological effects of Salvia miltiorrhiza-derived interventions on osteoporosis in animal models. The analysis, authored by Yuanna Zhang and last updated in May 2026, extracted data on bone mineral density, bone morphology, and biochemical markers. Results indicate significant improvements in bone density and key metabolism markers, with the most significant effects observed in ovariectomy models.

Use Cases

• Training models to predict the efficacy of herbal interventions based on reported bone mineral density (BMD) outcomes.
• Analyzing the relationship between intervention dose/duration and bone metabolism markers like PINP and TRACP.
• Conducting subgroup meta-analyses on specific animal models, such as ovariectomy (OVX), using the aggregated study results.

Strengths

• Includes data extracted from 24 eligible randomized controlled trials.
• Reports specific statistical outcomes, such as a standardized mean difference (SMD) of 1.95 for Bone Mineral Density improvement.
• Risk of bias was assessed using the SYRCLE tool, and analyses were performed with Stata and Review Manager software.

Limitations

• The dataset is a 14.7 KB DOCX file, indicating a very limited scope, likely containing only the review's supplementary document rather than raw experimental data.
• Column-level documentation is absent; field semantics must be inferred after download.
• The findings are based on animal models, which the authors note have limited translational validity to human disease.

Provenance

Source

Yuanna Zhang, via figshare.

Collection Method

Systematic literature search across seven Chinese and English databases, followed by meta-analysis of extracted study data.

Freshness

Last updated 2026-05-26 08:17:07