Phase I Cardiovascular Clinical Trials in Europe, 488 Studies from 5 Countries

488 Phase I clinical trials for cardiovascular diseases and risk factors were analyzed from ClinicalTrials.gov up to December 2024. The data reveals geographic disparities, with Germany and the UK conducting the most trials and Italy the fewest, and a focus on industry sponsorship. Author Stefano Grosdani compiled this analysis, which was last updated in May 2026.

Use Cases

• Analyze geographic distribution of early-phase research based on country-level trial counts
• Compare industry versus non-industry sponsorship trends based on the 84% industry-sponsored figure
• Study focus areas within cardiometabolic research based on the classification into CVDs and CVRFs
• Investigate recruitment strategies based on the proportion of studies enrolling healthy volunteers

Strengths

• Focuses on 488 Phase I trials after applying specific filters, providing a curated subset
• Includes detailed breakdowns by country, sponsor type, and disease condition (e.g., 35% CVDs, 65% CVRFs)
• Classifies conditions into 12 ICD-11-based groups and two macro-categories for structured analysis

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data may reflect geographic bias inherent to the selection of five specific European countries

Provenance

Source

ClinicalTrials.gov

Collection Method

Analysis of registered Phase I clinical trials, filtered for specific diseases and European countries.

Time Range

From database inception to December 2024

Freshness

Last updated 2026-05-12 05:42:10; freshness should be verified

Geography

Five European countries: France, Germany, Italy, Spain, and the United Kingdom