Supplementary File on PEPCK Inhibition in Inflammatory T Cells

Rebecca J. Brownlie's research article, published on figshare in April 2026, investigates the role of phospho-enol pyruvate carboxykinases in T cell metabolism. The 6.8 MB DOCX file details how PEPCK-M upregulation supports effector functions like cytokine production and cytotoxicity. Inhibition of PEPCK is shown to limit these functions by reducing mitochondrial respiration.

Use Cases

• Analyzing the metabolic pathways of activated T cells based on the described PEPCK expression and inhibition.
• Modeling the link between mitochondrial respiration and cytotoxic capacity in CD8+ T cells based on the reported findings.
• Investigating transcriptional and enzymatic regulation of T cell anaplerosis and cataplerosis as referenced in the introduction.

Strengths

• File size is 6.8 MB, indicating a detailed supplementary document.
• Published under a permissive CC-BY-4.0 license, allowing reuse and redistribution.
• Last updated date is explicitly provided (2026-04-13).

Limitations

• Row count and column-level documentation are absent; data structure must be inferred after download.
• The dataset is a single 6.8 MB DOCX file, which may limit direct computational analysis without text extraction.

Provenance

Source

figshare, authored by Rebecca J. Brownlie.

Collection Method

Likely contains experimental data and analysis from a biological study, as described in the methods section.

Time Range

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Freshness

Last updated 2026-04-13 05:46:14.

Geography

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