Phosphosulindac Effects on Corneal Sensitivity in Rabbit Dry Eye Model

A preclinical study by Wei Huang, last updated in 2026, investigates the therapeutic effects of phosphosulindac (PS) on dry eye disease (DED) in rabbits. The dataset likely contains measurements of corneal sensitivity, tear osmolarity, tear break-up time, and Schirmer tear test results before and after DED induction. It compares the efficacy of PS in various formulations against other ocular drugs.

Use Cases

• Evaluate the efficacy of different drug formulations (hydrogel, emulsion, nanoparticle) based on the described therapeutic testing.
• Analyze the relationship between corneal sensitivity and clinical DED metrics like tear osmolarity and break-up time mentioned in the methods.
• Compare the effects of phosphosulindac to other compounds like cyclosporine and lifitegrast based on the results described.
• Investigate concentration- and pH-dependent effects on corneal sensitivity in normal versus diseased eyes as described in the results.

Strengths

• Specific therapeutic dose (0.2%) and optimal pH (6.2) are identified for the compound.
• Compares multiple drug formulations and seven structurally related compounds, providing a basis for comparative analysis.
• Includes temporal data on effect duration (~26 hours) and reversibility.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (127.2 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Experimental data from a controlled preclinical study using New Zealand white and Dutch-belted black rabbits.

Freshness

Last updated 2026-06-03 06:01:17; freshness should be verified.