Plasma Proteome Mendelian Randomization for Gastric Cancer Drug Targets

A proteome-wide Mendelian randomization study identifies ancestry-specific plasma protein targets for gastric cancer. The dataset likely contains results from analyses of European and East Asian populations, published by Peng Zhi in 2026. It delineates 13 protein targets, including five novel candidates, associated with gastric cancer susceptibility.

Use Cases

• Identify potential drug targets for gastric cancer based on ancestry-specific plasma protein associations.
• Prioritize proteins for experimental validation based on Mendelian randomization and colocalization results.
• Explore repurposable drugs for gastric cancer based on molecular docking results mentioned in the description.
• Compare genetic associations for gastric cancer risk between European and East Asian populations.
• Investigate cellular expression patterns of candidate proteins in gastric tumor tissue using single-cell RNA sequencing data.

Strengths

• Identifies 13 ancestry-specific protein targets, including five novel candidates.
• Includes experimental validation results for NME4 and ICAM5 in gastric cancer cell lines and tissue samples.
• Licensed under CC-BY-4.0 for open reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a 1.4 MB PDF, which may require extraction of underlying data.

Provenance

Source

figshare

Collection Method

Mendelian randomization and colocalization analyses of plasma proteome data.

Freshness

Last updated 2026-05-01 04:19:35; freshness should be verified.

Geography

European and East Asian populations