Rat Breast Cancer Model Data on PI3K/Akt/mTOR Pathway Modulation

64 female Sprague-Dawley rats were used in a DMBA-NMU induced breast cancer model to evaluate the effects of Pleurotus ostreatus extract and vincristine. The dataset likely contains measurements of antioxidant status, hormonal profiles, histopathology, and PI3K/Akt/mTOR pathway protein expression levels after 25 weeks. Magdalene Eno Udobi published the data on figshare in April 2026.

Use Cases

• Analyze the correlation between PI3K/Akt/mTOR pathway protein expression and tumor development based on immunohistochemistry data.
• Compare the efficacy of natural extract versus standard chemotherapy based on hormonal profile and antioxidant status measurements.
• Model the synergistic effects of combination therapies based on changes in ER, PR, Akt, and MDM2 levels.
• Investigate the restoration of tumor suppressors PTEN, GSK3β, and FOXO following treatment.
• Evaluate the impact of treatments on hormonal imbalance based on estradiol and progesterone level changes.

Strengths

• Data is derived from a controlled animal study with 64 subjects across eight treatment groups.
• Analysis includes multiple quantitative endpoints: fold changes in key proteins (e.g., PI3K +21-fold), percentage changes in enzymes (e.g., SOD -26.7%), and hormonal levels.
• Statistical analysis was performed using GraphPad Prism 8.0 with one-way ANOVA.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is 1.1 MB, suggesting a relatively small scale of data.

Provenance

Source

figshare

Collection Method

Experimental data from a preclinical animal study.

Time Range

Study duration of 25 weeks.

Freshness

Last updated 2026-04-10 06:03:25; freshness should be verified.