Poge Heart-Saving Decoction Metabolite and Mouse Heart Failure Study

A supplementary research document details a study on the Poge Heart-Saving Decoction (PHSD) for heart failure. The work identifies 133 metabolites in PHSD and presents in vivo mouse model results, including echocardiography, histopathology, and protein/mRNA expression analyses. The author is Lei Du, and the file was last updated in March 2026.

Use Cases

• Analyze the 133 identified PHSD metabolites for potential bioactive compound discovery.
• Examine protein expression data for BAX, BCL-2, PI3K, and AKT to validate apoptosis and fibrosis pathway inhibition.
• Review echocardiography and NT-proBNP level results to assess cardiac function improvement in the ISO-induced mouse model.
• Study histopathological examination findings on myocardial tissue for collagen I and III deposition changes.

Strengths

• Identifies a specific count of 133 metabolites within the Poge Heart-Saving Decoction.
• Reports experimental results from a controlled in vivo mouse model, including multiple data types (echocardiography, histology, molecular biology).
• Released under a permissive CC BY 4.0 license for reuse and redistribution.

Limitations

• The dataset is a single 266.0 KB DOCX file, presenting limited scope and scale for computational analysis.
• Contains no structured, machine-readable tabular data (rows/columns unknown), requiring manual extraction of figures and results.
• Findings are based on a specific animal model (ISO-induced mouse HF), which may not directly translate to human physiology.

Provenance

Source

figshare, authored by Lei Du.

Collection Method

Experimental study using UHPLC-MS/MS for metabolite characterization and a mouse model with isoproterenol-induced heart failure.

Freshness

Last updated March 2026.