Supplementary file 1_Postmarketing surveillance of elobixibat for patients with chronic co

A prospective, multicenter study of 332 patients with schizophrenia or depression assessed the safety and effectiveness of the laxative elobixibat in real-world settings between June 2018 and May 2022. Adverse drug reaction rates ranged from 2.33% to 9.09%, with diarrhea being the most common, and no serious ADRs were reported. Mean weekly defecation frequency increased from approximately 3 at baseline to over 5 after 4 weeks of treatment, and the proportion of patients with ideal stool form scores reached about 60% by week 52.

Use Cases

• Analyzing adverse drug reaction rates and types based on the reported safety outcomes for patients with schizophrenia or depression.
• Modeling treatment effectiveness based on changes in defecation frequency and Bristol Stool Form Scale scores.
• Studying real-world drug utilization patterns based on the reported concurrent use of antipsychotics and anxiolytics.
• Comparing short-term (4-week) versus long-term (52-week) safety and efficacy outcomes for a novel laxative.

Strengths

• Prospective, multicenter design with a registered clinical trial (jRCT1080223950).
• Includes specific patient counts for two treatment duration groups (4-week and 52-week).
• Reports concrete effectiveness metrics, including mean defecation frequency and Bristol Stool Form Scale score proportions.
• Explicitly states the surveillance period (June 2018 to May 2022) and follow-up observation windows.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is limited to a Japanese patient population, which may affect generalizability.

Provenance

Source

Author Yoshiteru Takekita, published on figshare.

Collection Method

Prospective, multicenter postmarketing surveillance study.

Time Range

Surveillance conducted between June 2018 and May 2022.

Freshness

Last updated 2026-04-20 05:22:22; freshness should be verified.

Geography

Japan