JPYSZGT: Clinical and Metabolomic Data from a Rheumatoid Arthritis-Sarcopenia Pilot Study

A pilot study dataset from a 12-month clinical trial investigating the Jianpi Yishen Zhuanggu Tongluo formula for rheumatoid arthritis with sarcopenia-osteopenia. The data includes clinical outcomes for 40 patients, such as inflammatory markers, bone density, and muscle mass, alongside metabolomics analysis. The dataset was authored by Weidong Liang and last updated on 2026-04-21.

Use Cases

• Compare treatment efficacy based on clinical metrics like DAS28-ESR, BMD, and ASMI between intervention and control groups.
• Analyze metabolic pathway alterations based on the 14 identified pathways involving glucose, lipid, and amino acid metabolisms.
• Investigate correlations between inflammatory markers (CRP, ESR, TNF-α, IL-6) and bone metabolism markers (CTX, PINP, IGF).
• Explore potential mechanistic insights related to the PINK1/PARKIN and OPG/RANK pathways suggested by in vitro experiments.

Strengths

• Includes data from a registered clinical trial (ChiCTR2500106729) with a defined protocol.
• Contains results from multiple assessment methods: clinical outcomes, 1H-NMR metabolomics, and in vitro experiments.
• Reports on 40 patients randomized into two groups over a 12-month intervention period.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• The dataset is very small (16.2 KB), suggesting it may be a summary document rather than raw patient-level data.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare, authored by Weidong Liang.

Collection Method

Data was collected from a randomized pilot clinical trial.

Time Range

The clinical trial lasted 12 months; specific start/end dates are not provided.

Freshness

Last updated 2026-04-21 05:36:11; freshness should be verified.