Preclinical Meta-Analysis of Moringa Oleifera for Peptic Ulcer Disease

Presenting a systematic review and meta-analysis of 11 preclinical studies involving 268 animals, evaluating the therapeutic effect of Moringa oleifera extracts on peptic ulcer disease. It includes pooled analysis of ulcer index data, subgroup analyses by dose and comparator, and assessments of heterogeneity and publication bias.

Use Cases

• Analyze the relationship between Moringa oleifera dose and ulcer index reduction across 11 included studies.
• Compare the standard mean difference (SMD) for ulcer index between high-dose Moringa and standard drug comparators.
• Examine heterogeneity (I²) and publication bias results from the meta-analysis methodology.
• Assess study quality using the reported SYRCLE scores ranging from 8 to 9.

Strengths

• Includes data from 11 studies involving 268 animals, providing a consolidated preclinical evidence base.
• Reports specific quantitative results, including a pooled standard mean difference (SMD) of -1.42 for ulcer index.
• Conducts subgroup analyses based on dose and comparator, revealing variability in outcomes.
• Assesses study quality with SYRCLE scores and statistical heterogeneity with I² values.

Limitations

• The dataset is a single 376.7 KB document, not a structured tabular dataset, limiting computational analysis.
• Limited to preclinical (rodent) studies; no clinical trial data is included.
• The meta-analysis notes methodological heterogeneity among the included studies.

Provenance

Source

figshare, authored by Saheed Olatunbosun Akiode.

Collection Method

Systematic review and meta-analysis of eligible studies from PubMed, CINAHL, Scopus, Web of Science, and Cochrane Library.

Time Range

Literature search from database inception to August 2025.

Freshness

Last updated March 20, 2026, with literature search up to August 2025.