Supplementary file 1_Premature ovarian insufficiency in patients with systemic lupus eryth

Manuel Ramón García-Sáenz authored a systematic review and meta-analysis investigating premature ovarian insufficiency in women with systemic lupus erythematosus treated with cyclophosphamide. The analysis, registered with PROSPERO, pooled data from 12 cyclophosphamide-exposed cohorts and estimated a pooled prevalence of 15%. The document, last updated in May 2026, includes results from a search of five databases from inception through October 2024.

Use Cases

• Estimating the prevalence of cyclophosphamide-induced ovarian insufficiency based on the pooled meta-analysis result of 15%.
• Investigating sources of heterogeneity in clinical outcomes based on factors like patient age at exposure and study publication year.
• Comparing treatment protocol effects based on the temporal analysis showing reduced prevalence after the adoption of low-dose Euro-Lupus protocols.
• Assessing methodological robustness in meta-analyses based on the described sensitivity analyses using logit transformation and GLMM models.

Strengths

• Includes a meta-analysis of 12 cyclophosphamide-exposed cohorts, providing a quantitative summary estimate.
• Reports specific statistical results, including a pooled prevalence of 15% with a 95% CI of 7-26% and meta-regression coefficients.
• Conducted a comprehensive literature search across five major databases (MEDLINE, Embase, Web of Science, Scopus, LILACS) up to October 2024.
• Assessed study quality using a standardized checklist (Joanna Briggs Institute) and evaluated publication bias.

Limitations

• The underlying dataset is a 6.4 MB DOCX file; the raw data tables and column definitions are not directly accessible for computational analysis.
• Row count and individual patient-level data are unknown, limiting suitability for direct machine learning applications.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

Manuel Ramón García-Sáenz

Collection Method

Systematic review and meta-analysis of published studies.

Time Range

Literature search from database inception through October 2024.

Freshness

Last updated 2026-05-28 04:53:04; freshness should be verified.