Meta-Analysis of Prenatal Maternal Distress and Autism Spectrum Disorder Risk in Offspring

A meta-analysis document synthesizing results from 22 observational studies on the association between prenatal maternal psychological distress and autism spectrum disorder risk in offspring. The analysis, conducted by Dan Lin and registered with PROSPERO, includes studies searched up to June 2025 and reports a pooled odds ratio of 1.72. The 706.2 KB document was last updated on April 20, 2026.

Use Cases

• Conducting secondary analysis of the pooled effect size (OR=1.72) for risk modeling
• Reviewing methodological heterogeneity (I²=87.90%) across included observational studies
• Informing maternal mental health screening protocols based on the synthesized association evidence

Strengths

• Includes a specific pooled odds ratio (OR=1.72) with a 95% confidence interval (1.50–1.97)
• Systematically reviewed 484 records and included 22 eligible studies up to June 2025
• Registered with PROSPERO (CRD420251119825), indicating a structured review protocol
• Released under a CC-BY-4.0 license, permitting reuse with attribution

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is a 706.2 KB DOCX file, indicating a limited scope as a summary document rather than raw study data
• Row count is unknown, which may limit suitability assessment for quantitative reuse

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of observational studies from six electronic databases.

Time Range

Studies searched up to June 2025.

Freshness

Last updated 2026-04-20 05:23:00; freshness should be verified

Geography

No geographic restrictions were applied to the included studies.