Statin Use and Colorectal Cancer Survival: A Meta-Analysis of 25 Studies

A systematic review and meta-analysis by Gang Li, published on figshare in 2026, synthesizes evidence on the association between statin use and survival in colorectal cancer patients. It aggregates data from 25 observational studies involving 179,979 patients, analyzing outcomes like all-cause and cancer-specific mortality. The analysis employs hazard ratios with 95% confidence intervals, using a random-effects model.

Use Cases

• Conducting secondary meta-analyses based on the pooled hazard ratios for all-cause mortality (ACM) and cancer-specific mortality (CSM).
• Investigating differential effects of pre-diagnosis versus post-diagnosis statin use on patient survival outcomes.
• Assessing the quality of observational studies in oncology using the Newcastle-Ottawa Scale methodology described.
• Validating findings on non-significant associations for disease-free mortality (DFM) and recurrence-free mortality (RFM).

Strengths

• Aggregates data from 25 studies with a total of 179,979 colorectal cancer patients.
• Provides specific pooled hazard ratios and 95% confidence intervals for multiple survival outcomes (e.g., ACM: HR 0.80).
• Distinguishes between pre-diagnosis and post-diagnosis statin use in its analysis.
• Uses a peer-reviewed systematic review methodology with a registered protocol (INPLASY2025110064).

Limitations

• The primary data file is a 29.7 KB DOCX document, which is a small text file containing the review manuscript, not a raw dataset.
• Row count and column-level documentation for any underlying data are unknown.
• The data reflects findings from observational studies, which may have inherent biases not fully addressed by meta-analysis.

Provenance

Source

figshare, authored by Gang Li.

Collection Method

Systematic literature review and meta-analysis of studies from PubMed, Embase, Cochrane Library, and Web of Science.

Time Range

Studies from database inception until October 31, 2025.

Freshness

Last updated 2026-03-18 05:21:16.

Geography

Global, as the review includes international studies.