Resveratrol Effects in Spinal Cord Injury Animal Models: A Preclinical Meta-Analysis

38 controlled in vivo studies form the basis of this systematic review and meta-analysis on resveratrol's neuroprotective effects in animal models of spinal cord injury. The analysis, authored by Yingchun Li and last updated in May 2026, pools outcomes for locomotor recovery, oxidative stress, inflammation, apoptosis, and edema. Results show resveratrol significantly improved locomotor scores and attenuated key pathological markers, though molecular evidence for apoptosis pathways was heterogeneous.

Use Cases

• Evaluating the efficacy of resveratrol for locomotor recovery based on pooled BBB and BMS scores from animal models.
• Analyzing the compound's impact on oxidative stress based on reported MDA, SOD, and GSH level changes.
• Investigating anti-inflammatory effects based on pooled MPO, TNF-α, IL-1β, and IL-6 level data.
• Assessing effects on apoptosis and edema based on TUNEL-positive rates and spinal cord water content.

Strengths

• Systematic methodology covering 38 controlled in vivo studies, providing a quantitative synthesis of evidence.
• Analysis includes multiple outcome domains: locomotor function, oxidative stress, inflammation, apoptosis, and edema.
• Results are presented with standardized mean differences and 95% confidence intervals for key time points post-injury.
• Dataset is openly shared under a CC-BY-4.0 license, facilitating reuse and verification.

Limitations

• The dataset is a 23.5 KB DOCX file containing the review manuscript, not the underlying raw study data.
• Row and column structures for the meta-analysis data are unknown, requiring extraction from the document.
• The description is detailed for the review's conclusions but lacks direct documentation of the compiled dataset's variables.

Provenance

Source

figshare, authored by Yingchun Li.

Collection Method

Systematic review and meta-analysis of published controlled in vivo studies.

Freshness

Last updated 2026-05-21 04:31:28