Proteomic Profiles of Spontaneous Myopia in Guinea Pigs

Hong Liu's study provides proteomic data from 23 guinea pigs, comprising 11 with spontaneous myopia and 12 hyperopic controls. The dataset includes measurements of refractive error, ocular biometrics, retinal thickness, and proteomic profiles from retinal and plasma samples. It was published on figshare under a CC-BY-4.0 license and last updated on March 19, 2026.

Use Cases

• Identify protein biomarkers for myopia based on retinal and plasma proteomic profiles.
• Compare ocular biometric parameters like axial length and vitreous chamber depth between myopic and hyperopic animal models.
• Investigate molecular pathways such as complement activation and ferroptosis in myopic retinal tissue.
• Validate the guinea pig as an animal model for human high myopia research based on fundus and proteomic similarity.

Strengths

• Includes data from 23 animals (11 myopic, 12 hyperopic), providing a controlled comparison.
• Multimodal measurements: refractive error, ocular biometrics (SS-OCT), histology (H&E, TUNEL), and proteomics (Rapid-DIA).
• Proteomic analysis covers both retinal tissue and plasma samples, allowing for systemic biomarker investigation.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (18.5 KB), indicating limited scope, likely containing summary results rather than raw experimental data.

Provenance

Source

figshare, author Hong Liu.

Collection Method

Experimental study using infrared eccentric photorefraction, swept-source optical coherence tomography (SS-OCT), electroretinography (ffERG), histology, and rapid data-independent acquisition (Rapid-DIA) proteomics.

Freshness

Last updated 2026-03-19 05:19:59; freshness should be verified.