Rare Genetic Variants in Alzheimer's Disease from a Saudi Cohort

A collection of 107 rare candidate genetic variants identified via whole-exome sequencing in 64 Saudi patients with sporadic and familial Alzheimer's disease. The data was generated by Fadia El Bitar and published on figshare in May 2026. Of the variants, 26 were novel and 33 were linked to Alzheimer's disease pathology.

Use Cases

• Prioritizing candidate genes for Alzheimer's disease based on rare variant data from a non-European cohort.
• Comparing variant frequencies and novel discoveries across different populations.
• Investigating genetic links between Alzheimer's disease and other neurodegenerative disorders based on the functional categorization of variants.
• Studying pathways like Aβ and Tau pathology, kinase signaling, and neuroinflammation using the identified gene set.

Strengths

• Includes 107 rare candidate variants with functional relevance, providing a focused genetic resource.
• Data is derived from a specific and underrepresented population cohort of 64 Saudi patients.
• Variants are categorized by biological relevance, with 33 linked to AD and 28 linked to both AD and other neurodegenerative disorders.
• Published under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain analyses.
• The dataset is small in scale at 485.8 KB, representing a limited cohort.

Provenance

Source

figshare

Collection Method

Whole-exome sequencing (WES) performed on the Ion Proton platform, followed by an internal filtering and prioritization process.

Time Range

null

Freshness

Last updated 2026-05-08 05:51:58; freshness should be verified.

Geography

Saudi Arabia