Raspberry Extract Effects on MAFLD in Mice via Gut Microbiota and Purine Metabolism

A supplementary research document detailing a study on raspberry aqueous extract's effects on metabolism-associated fatty liver disease in a mouse model. The study used a 12-week high-fat diet to induce MAFLD in C57BL/6 mice and employed multi-omics analyses including 16S rRNA sequencing and metabolomics. The document was authored by Yanyan Gao and last updated on 2026-04-30.

Use Cases

• Study the relationship between gut microbiota composition and liver disease based on 16S rRNA sequencing results mentioned in the description
• Investigate purine metabolic reprogramming in MAFLD based on metabolite levels like inosine and ADP described in the results
• Examine the effects of specific bacterial genus Ileibacterium on hepatic lipid deposition based on in vivo colonization experiments
• Analyze the protective mechanisms of inosine against lipotoxicity in hepatocytes based on in vitro cell experiments

Strengths

• The study employs integrated multi-omics analyses including 16S rRNA sequencing and metabolomics.
• Experimental design includes a 12-week high-fat diet mouse model and specific intervention doses of 1 g/kg/d and 2 g/kg/d.
• Results identify specific mediators like the genus Ileibacterium and metabolite inosine.

Limitations

• The dataset is a 4.6 MB DOCX file, which is a small supplementary document rather than a primary data repository.
• Row count and column-level documentation are absent; data structure must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

The data likely originates from a preclinical animal study involving C57BL/6 mice fed a high-fat diet, with interventions and multi-omics analyses.

Freshness

Last updated 2026-04-30 04:16:23; freshness should be verified.