Ivacaftor Anti-Inflammatory Effects in a Murine Acute Lung Injury Model

A 453.4 KB supplementary document details a preclinical study evaluating the anti-inflammatory effects of ivacaftor in mice. The research, authored by Xiaoxuan Han and last updated in June 2026, compares intraperitoneal versus intratracheal drug delivery in an LPS-induced lung injury model. Data includes measurements of immune cell infiltration, histological changes, and drug concentrations quantified via mass spectrometry.

Use Cases

• Analyzing the comparative efficacy of different drug administration routes based on the intratracheal vs. intraperitoneal delivery comparison.
• Studying the anti-inflammatory mechanisms of CFTR modulators based on the described reduction in neutrophil infiltration and alveolar wall thickening.
• Validating mass spectrometry methods for drug quantification in tissue samples based on the use of MRM-LCMS for measuring ivacaftor concentrations.

Strengths

• The study design includes a direct comparison of two drug delivery routes (intraperitoneal vs. intratracheal).
• Outcomes are measured using multiple methods: cell counts, fluorescence-activated cell sorting (FACS), histology, and mass spectrometry.
• Results include specific quantitative findings, such as a ~40% reduction in total BALF cell counts at 24 hours.

Limitations

• The dataset is a 453.4 KB DOCX file, which is a small supplementary document rather than a primary data repository.
• Row count and column-level documentation are absent; data structure and granularity must be inferred from the text.
• The data is derived from a single, controlled murine model, which may limit direct translation to human clinical contexts.

Provenance

Source

figshare, authored by Xiaoxuan Han.

Collection Method

Data was generated from a controlled laboratory study using 8–10-week-old female C57BL/6 mice.

Freshness

Last updated 2026-06-01 04:21:02.