Network Meta-Analysis of Intracranial Hemorrhage Risk with Oral Anticoagulants

An updated network meta-analysis of 20 randomized controlled trials, including 127,267 patients, published on figshare in May 2026. The study compares the risk of intracranial hemorrhage between direct oral anticoagulants and Vitamin K Antagonists. The supplementary document contains the detailed results and methodology for this systematic review.

Use Cases

• Comparing the safety profiles of different anticoagulants based on the reported odds ratios and confidence intervals.
• Ranking drug safety for intracranial hemorrhage based on the SUCRA values provided in the results.
• Validating or informing clinical decision models with the synthesized evidence from 20 trials.
• Teaching or demonstrating network meta-analysis methodology using a documented case study.

Strengths

• Includes data from 127,267 patients across 20 randomized controlled trials, providing a substantial evidence base.
• Reports specific odds ratios and 95% confidence intervals for direct comparisons between drug classes.
• Provides a systematic ranking of drug safety using SUCRA values, with dabigatran ranked highest (87.6).
• Has a registered systematic review protocol (PROSPERO CRD420261336668), indicating a structured methodology.

Limitations

• The dataset is a 330.6 KB DOCX file; the underlying tabular data (e.g., trial-level data) is not directly accessible.
• Column-level documentation is absent; field semantics must be inferred from the document text after download.
• Row count is unknown, which may limit suitability assessment for direct computational analysis.

Provenance

Source

figshare, authored by Jiana Chen.

Collection Method

Systematic review and network meta-analysis of trials from PubMed, EMBASE, Web of Science, and Cochrane Library up to January 5, 2026.

Time Range

Trials searched up to January 2026.

Freshness

Last updated 2026-05-19 05:38:38; freshness should be verified against more recent studies.

Geography

Likely global, as the analysis aggregates international randomized controlled trials.