Neuroprotective Effects of SHPL-49 in BCCAO Rat Stroke Model

Supplementary data from a 28-day study on the salidroside derivative SHPL-49 in rats with bilateral common carotid artery occlusion (BCCAO). The research includes behavioral tests, synaptic protein analysis, and transcriptomic data from PC-12 cells. It was authored by Pei Zhang and published under a CC BY 4.0 license.

Use Cases

• Analyze behavioral performance metrics from Morris water maze, shuttle box, running wheel, gait analysis, and rotarod tests.
• Investigate changes in synaptic protein expression, including SYN1, MAP-2, SYP, and βIII-tubulin, from Western blot and immunofluorescence data.
• Validate the role of the CDK5/p35/p25 signaling pathway using transcriptomic data from SHPL-49-treated PC-12 cells.
• Examine dendritic spine density data from Golgi staining in brain tissue of BCCAO rats.
• Correlate in vitro findings from oxygen-glucose deprived primary neurons with in vivo outcomes in the BCCAO model.

Strengths

• Data originates from a controlled, multi-modal study employing behavioral, histological, and molecular biology techniques.
• Includes transcriptomic analysis from RNA sequencing of PC-12 cells to identify SHPL-49-regulated genes.
• The dataset is openly available under a CC BY 4.0 license, facilitating reuse.

Limitations

• The dataset is a 451.4 KB DOCX file, indicating it is likely a summary document or supplementary figures, not a structured, machine-readable data table.
• No explicit column names or sample data are provided, limiting direct computational analysis.
• The data is specific to a single, pre-clinical rat model of ischemic stroke (BCCAO), which may not generalize to other models or human physiology.

Provenance

Source

figshare, authored by Pei Zhang.

Collection Method

Experimental data from a laboratory study using BCCAO rat models, in vitro PC-12 cell cultures, and primary neuron OGD/R models.

Time Range

Study involved a 28-day treatment period.

Freshness

Last updated on 2026-03-23.