Serum Metabolomic Profiles for Predicting Immunotherapy Response in Allergic Rhinitis

Serum metabolomic data from a clinical study of 32 patients with house dust mite-induced allergic rhinitis undergoing subcutaneous immunotherapy. The dataset includes untargeted metabolomics and targeted bile acid profiling results from paired pre- and post-treatment samples, used to identify biomarkers of treatment response. The data was generated by researchers from Peking Union Medical College Hospital and the Affiliated Hospital of Qingdao University and published on figshare in 2026.

Use Cases

• Identify predictive serum biomarkers for immunotherapy response based on metabolomic profiles.
• Validate the role of specific bile acids, like taurolithocholic acid, in modulating immune response.
• Correlate clinical symptom scores (VAS, TNSS, RQLQ) with molecular changes from untargeted metabolomics.
• Investigate differential metabolic pathways, such as bile secretion, associated with treatment efficacy.

Strengths

• Data from a prospective clinical study with 32 patients, including 22 responders and 10 non-responders.
• Includes paired pre- and post-treatment serum samples analyzed via untargeted metabolomics (956 differential metabolites identified) and targeted bile acid profiling.
• Findings validated in an HDM-induced allergic rhinitis mouse model, linking biomarker to immune cell changes.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is small (558.9 KB), suggesting limited scope, potentially focusing on summary-level results rather than raw patient-level data.

Provenance

Source

figshare, author Jing Zhang.

Collection Method

Prospective clinical study with serum samples analyzed via liquid chromatography–mass spectrometry.

Freshness

Last updated 2026-05-11 05:29:42; freshness should be verified.

Geography

Patients enrolled from medical centers in China (Peking Union Medical College Hospital and the Affiliated Hospital of Qingdao University).