Severity-Stratified Genetic Diagnosis Results for Isolated Fetal Growth Restriction

A retrospective study of 164 singleton pregnancies with isolated fetal growth restriction (FGR) stratified by severity. The dataset, uploaded by Ying Li in March 2026, contains results from trio exome sequencing, reporting diagnostic yields of 8.3% for non-severe and 18.0% for severe FGR cases.

Use Cases

• Compare diagnostic yield of exome sequencing based on fetal growth restriction severity
• Analyze associations between genetic variants and pregnancy outcomes like termination
• Investigate correlations between severe FGR and clinical factors like preeclampsia and abnormal Doppler waveforms
• Support genetic counseling strategies for variants of uncertain significance in prenatal cases

Strengths

• Includes results for 164 pregnancies, providing a basis for severity-stratified analysis
• Reports specific diagnostic yields: 8.3% (3/36) for non-severe and 18.0% (16/89) for severe FGR
• Data is openly shared under a CC-BY-4.0 license

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is very small at 8.9 KB, indicating limited scope

Provenance

Source

figshare

Collection Method

Retrospective study using trio exome sequencing on clinical samples.

Time Range

Study period not specified in the provided metadata.

Freshness

Last updated 2026-03-18 07:45:50; freshness should be verified

Geography

Geographic coverage not specified in the provided metadata.