Supplementary file 1_Shared molecular features and candidate pathways underlying gastric c

Bin Liu's research article analyzes the genetic and molecular correlations between gastric cancer and depression. The work identifies 130 gastric cancer-associated and 534 depression-associated genes from public databases, with six hub genes and associated pathways highlighted. The supplementary file was last updated on May 20, 2026, and is shared under a CC-BY-4.0 license.

Use Cases

• Identify candidate hub genes like SERPINE1 and COL4A1 based on the overlapping gene analysis described
• Investigate immune cell infiltration patterns based on the single-sample Gene Set Enrichment Analysis mentioned
• Construct miRNA-mRNA regulatory networks based on predicted targets like miR-21-5p and miR-145-5p
• Validate potential molecular linkages through pathways such as PI3K-Akt and AGE-RAGE described in the analysis

Strengths

• Identifies six specific hub genes (SERPINE1, COL4A1, PDGFRB, BMP1, NOTCH3, EDNRA) from the analysis
• Integrates data from three public databases (Gene Expression Omnibus, DisGeNET, GeneCards)
• Includes experimental validation via real-time quantitative PCR and Western blot as mentioned in the description

Limitations

• The 49.4 KB file size suggests limited raw data, likely containing analysis results or a manuscript
• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Data integration and analysis from Gene Expression Omnibus, DisGeNET, and GeneCards databases.

Freshness

Last updated 2026-05-20 08:07:28; freshness should be verified