Shenfu Injection Mechanisms and Evidence for Sepsis-Induced Gastrointestinal Injury

A narrative review summarizing mechanistic, preclinical, and clinical evidence for Shenfu Injection in treating sepsis-induced acute gastrointestinal injury. The review, authored by Xiufeng Pang, was published on figshare in May 2026. It aggregates findings from a structured search of major English- and Chinese-language databases.

Use Cases

• Reviewing mechanistic pathways for a botanical drug based on the described TLR4/NF-κB signaling and tight junction protein upregulation.
• Analyzing the current state of clinical evidence for a traditional Chinese medicine based on the described small sample sizes and single-center designs.
• Identifying research gaps in sepsis treatment based on the described need for high-quality multicenter trials and further mechanistic studies.

Strengths

• License is CC-BY-4.0, permitting broad reuse.
• The review critically appraises strengths and limitations of the current evidence base.

Limitations

• The dataset is a 445.5 KB ZIP file, indicating a very limited scope and likely containing only the review document.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Structured literature search of major English- and Chinese-language databases.

Freshness

Last updated 2026-05-01 05:27:42; freshness should be verified.