SHP2 in TAMs: Molecular Data on Gastric Adenocarcinoma Survival Pathways

A research document by Jing Bai, last updated April 30, 2026, details molecular mechanisms in gastric cancer. It describes experimental results from bulk RNA-seq analysis of the GSE118916 dataset and co-culture models of THP-1 and AGS cells. The 105.1 KB DOCX file concludes that SHP2 in tumor-associated macrophages promotes cancer survival by inhibiting specific inflammatory pathways.

Use Cases

• Study the role of SHP2 in macrophage polarization based on protein expression data for Arg-1 and Cathepsin K.
• Investigate inflammation and ROS pathways in gastric cancer based on cytokine data for IL-1β, TNFα, MDA, and SOD.
• Analyze gene expression correlations in gastric cancer using results from bulk RNA-seq of the GSE118916 dataset.
• Model the effects of SP1 and BRD4 inhibition on cancer cell behavior based on described migration, invasion, and death assays.

Strengths

• Dataset is associated with a specific, cited GEO dataset (GSE118916) for RNA-seq analysis.
• Experimental methods are described, including the use of specific cell lines (THP-1, AGS) and inhibitors (JQ-1).
• File is openly licensed under CC-BY-4.0, permitting reuse with attribution.

Limitations

• The primary file is a 105.1 KB DOCX document; the underlying raw data files (e.g., RNA-seq counts) are not directly provided.
• Row count and column-level documentation for any potential tabular data are unknown.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, author Jing Bai.

Collection Method

Bulk RNA-seq analysis of a public GEO dataset and in vitro cell culture experiments.

Freshness

Last updated 2026-04-30 04:18:14; freshness should be verified.