Murine Hepatic Immune Cell Profiles from Single-Cell CyTOF, 20.8 MB

A 20.8 MB dataset from figshare, last updated in April 2026, containing single-cell mass cytometry (CyTOF) data profiling immune cell subsets in mouse livers during aging. The data, authored by Zheng Ding under a CC-BY-4.0 license, reveals age-associated alterations in B cells, CD4+ T cell subsets, and macrophages.

Use Cases

• Identify age-related shifts in immune cell populations based on the described alterations in Igd+ B cells and CD4+ T cell subsets.
• Analyze pathway enrichment in aged immune cells based on the described downregulation of migration and receptor binding genes.
• Characterize pro-inflammatory macrophage subsets in aging tissues based on the reported increase in resident-derived M1 macrophages.
• Model murine hepatic immune aging signatures based on the delineated alterations in B, T, and macrophage subsets.

Strengths

• Data is openly licensed under CC-BY-4.0, facilitating reuse and redistribution.
• The 20.8 MB file size indicates a manageable download and processing scale.
• The description provides specific biological findings, such as the reduction of Igd+ B cells and expansion of specific CD4+ T cell subsets.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analyses.
• The dataset is focused on a murine model, which may limit direct translation to human biology.

Provenance

Source

figshare

Collection Method

Single-cell mass cytometry (CyTOF) profiling of murine liver samples.

Time Range

Temporal coverage related to murine aging stages is implied but not explicitly stated.

Freshness

Last updated 2026-04-28 04:25:15; freshness should be verified.

Geography

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