Meta-Analysis of Sinomenine Effects in Rodent Rheumatoid Arthritis Models

A 2025 systematic review and meta-analysis synthesizing preclinical evidence from 38 animal studies on sinomenine's efficacy for rheumatoid arthritis. The document, authored by Ge Li and published under CC-BY-4.0, analyzes clinical, anti-inflammatory, and joint-protective outcomes from studies retrieved up to November 2025.

Use Cases

• Evaluating the dose-response relationship of sinomenine based on subgroup analysis results
• Assessing the impact of administration routes (e.g., intraperitoneal injection) on therapeutic efficacy
• Analyzing publication bias in preclinical research based on funnel plot results mentioned
• Investigating mechanisms of action for sinomenine based on analyzed cytokine and biomarker levels

Strengths

• Systematic methodology covering 4 English and 4 Chinese databases up to November 2025
• Includes 38 qualified animal studies with quality assessed using the SYRCLE bias risk tool
• Results supported by sensitivity analysis showing robust findings

Limitations

• Data is contained in a DOCX document; column-level documentation is absent and data must be extracted manually
• The findings are limited to rodent models, with acknowledged species differences and potential publication bias
• Row count for underlying data is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of preclinical studies.

Time Range

Studies included up to November 2025.

Freshness

Last updated 2026-05-04 05:30:33

Geography

Studies likely from international sources, but specific geography is not stated.