Porcine Enteroid Infection Model Data for Chlamydia suis and C. trachomatis

Margaux Verhaeghe authored a study evaluating porcine jejunum-derived enteroids as an in vitro model for intestinal infection by Chlamydia suis and Chlamydia trachomatis. The research assessed bacterial uptake, inclusion formation, and replication using microscopy and molecular approaches, published on figshare in April 2026. The dataset likely contains experimental results and analysis supporting the model's suitability for studying early host–pathogen interactions.

Use Cases

• Compare infection dynamics between C. suis and C. trachomatis based on microscopy and molecular data mentioned in the description
• Study dose-dependent infection levels in primary intestinal epithelial cells based on the experimental approach described
• Evaluate antibiotic efficacy on chlamydial infection based on tetracycline treatment results mentioned
• Investigate bacterial attachment and early inclusion formation in a physiologically relevant intestinal model based on the study's conclusions

Strengths

• Data originates from a specific experimental study using porcine enteroid monolayers, providing a physiologically relevant model.
• The study compares two pathogens, Chlamydia suis and Chlamydia trachomatis, allowing for comparative analysis.
• Results include functional confirmation via antibiotic treatment, demonstrating model responsiveness.

Limitations

• Dataset is a single 2.8 MB DOCX file; actual data tables, column definitions, and row counts are unknown.
• The description indicates limited replication of the chlamydial developmental cycle under the tested conditions.
• Freshness should be verified; the last update date is 2026-04-29, which is a future date.

Provenance

Source

figshare

Collection Method

Experimental research using microscopy-based and molecular approaches on porcine enteroid monolayers.

Freshness

Last updated 2026-04-29 05:57:26; freshness should be verified.