Mouse Dentate Gyrus Gene Expression After Denervation Across 5 Time Points

A 28-day time series of whole-genome expression analysis from laser-microdissected mouse dentate gyrus tissue following perforant path transection. The dataset likely contains transcriptomic measurements from the outer molecular layer and granule cell layer at 1, 3, 7, 14, and 28 days post-lesion. It was created by Jessica Schlaudraff and shared on figshare.

Use Cases

• Analyze temporal patterns of glial and inflammatory factor upregulation based on the description of reactive astrogliosis and microgliosis.
• Identify compensatory synaptic remodeling mechanisms based on the description of postsynaptic and dendritic membrane regulator changes.
• Study layer-specific transcriptional responses based on the comparison between outer molecular layer and granule cell layer data.

Strengths

• Data covers a 28-day time series with measurements at five specific post-lesion intervals.
• Tissue was selectively isolated using laser microdissection, suggesting precise spatial sampling.
• The dataset is 13.0 MB, indicating a focused, downloadable size.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The description is detailed but specific sample data and column names are unavailable.

Provenance

Source

figshare

Collection Method

Whole-genome expression analysis performed on laser-microdissected tissue from mouse dentate gyrus after perforant path transection.

Time Range

1, 3, 7, 14, and 28 days post-lesion.

Freshness

Last updated 2026-05-19 05:40:44; freshness should be verified.