ALTA Platform: Mouse Immune Response Data for Thermostable Vaccine Formulations

A supplementary research file describes immune response data from mice vaccinated with the Atomic Layering Thermostable Antigen and Adjuvant (ALTA®) platform. The data compares humoral and cellular responses against several liquid vaccine formulations, including Alhydrogel®, AddaVax™, and Alhydrogel® + CpG, using ovalbumin and Burkholderia pseudomallei antigens. The file, authored by Daria L. Ivanova and last updated on 2026-04-15, is a 1.7 MB PDF published under a CC-BY-4.0 license on figshare.

Use Cases

• Compare humoral immune responses (antibody titers) between ALTA® and liquid vaccine formulations based on ELISA data mentioned in the description.
• Analyze Th1/Th2 balance based on IgG2c and IgG1 antibody isotype data described.
• Evaluate CD8+ T-cell response enhancement from ALTA® formulations using flow cytometry data referenced.
• Assess antigen-presenting cell capture and antigen encapsulation effects on immune response based on mechanistic findings described.

Strengths

• Data includes comparisons across multiple adjuvant formulations (Alhydrogel®, AddaVax™, Alhydrogel® + CpG).
• Immune responses were measured using established techniques (ELISA and flow cytometry).
• Findings are validated with antigens from a clinically relevant pathogen (Burkholderia pseudomallei).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The primary data is embedded within a PDF, requiring extraction for computational analysis.

Provenance

Source

figshare

Collection Method

Experimental data from mouse vaccination studies, likely generated in a research laboratory.

Time Range

Experimental timeframe is not specified.

Freshness

Last updated 2026-04-15 05:42:05; freshness should be verified.

Geography

Geographic origin of the study is not specified.