MIMIC-IV Cohort Study: Survival and Hemodynamics with Beta-Blockers in Septic Shock

A retrospective cohort of 4,695 vasopressor-dependent patients with septic shock and incident tachyarrhythmia from the MIMIC-IV database. The data compares 28-day ICU mortality and longitudinal hemodynamic indices for patients treated with intravenous esmolol or metoprolol versus no beta-blocker. Author Guoxiang Zou published the dataset on figshare in May 2026 under a CC-BY-4.0 license.

Use Cases

• Compare 28-day mortality outcomes between different beta-blocker regimens based on the reported hazard ratios.
• Analyze longitudinal hemodynamic trajectories, including heart rate and blood pressure, for survivors and non-survivors.
• Investigate the association between lactate levels and blood pressure fluctuations in specific treatment groups.
• Conduct propensity score matching studies on real-world critical care data to control for confounding variables.

Strengths

• Includes 4,695 patient cases, with 1,494 (31.82%) 28-day mortality events, providing a substantial sample for analysis.
• Reports specific hazard ratios for mortality (e.g., metoprolol HR 0.28) and usage statistics (44.6% metoprolol, 1.9% esmolol).
• Longitudinal data tracks key hemodynamic indices like heart rate, blood pressure, and lactate over an 8-day period.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the specific analysis dataset is unknown, which may limit suitability assessment.
• Data may reflect the biases inherent to the single-center MIMIC-IV database used in the source study.

Provenance

Source

MIMIC-IV (Medical Information Mart for Intensive Care) database.

Collection Method

Retrospective cohort study using propensity score matching and restricted cubic splines analysis.

Freshness

Last updated 2026-05-22 06:10:16; freshness should be verified.