Mouse Toxicity and Immune Response Data for Glucose Oxidase-Loaded Extracellular Vesicles

A 10.5 MB supplementary document details preclinical safety studies of glucose oxidase-loaded extracellular vesicles (EVs). The data includes results from acute and repeated-dose toxicity studies in female BALB/c mice, assessing mortality, body weight, histopathology, and immune responses. The dataset, authored by Ireneusz P. Grudzinski and last updated in May 2026, is shared under a CC-BY-4.0 license.

Use Cases

• Assess acute toxicity profiles based on single-dose intravenous injection data in mice.
• Analyze repeated-dose immunotoxicity based on T-dependent antibody response (TDAR) and cytokine measurements.
• Compare immune modulation signatures based on chemokine and cytokine transcriptional response data.
• Evaluate the safety of enzyme-loaded EV delivery platforms based on histopathological and clinical observations.

Strengths

• Includes specific dosing information (e.g., 10^4–10^8 EVs mL^-1) and study durations (28-day repeated dose).
• Reports concrete immunological findings, such as a 1.5-fold increase in IgM levels and specific chemokine upregulation.
• Uses established preclinical models, including OECD 423 acute toxicity class method and vehicle/positive controls.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data format is a DOCX file, which may require conversion for computational analysis.

Provenance

Source

figshare

Collection Method

Experimental data from acute and repeated-dose toxicity studies in mice.

Freshness

Last updated 2026-05-11 05:25:35; freshness should be verified.