Supplementary Data for Arctiin's Cardioprotective Effects in Doxorubicin-Treated Mice

A supplementary document from a preclinical study investigating the natural compound Arctiin as a protective agent against doxorubicin-induced heart damage. The study used DOX-treated H9C2 cardiomyocytes and mouse models, assessing cardiac function, injury markers, oxidative stress, and lipid metabolism via lipidomics. The dataset, authored by Teng Teng and last updated in April 2026, is shared under a CC-BY-4.0 license.

Use Cases

• Analyzing the molecular mechanisms of SIRT1 protein stabilization based on the described binding and ubiquitination assays.
• Studying lipid metabolic dysregulation in drug-induced cardiomyopathy based on the lipidomics analysis mentioned.
• Investigating the role of the SIRT1/NRF2 pathway in mitigating oxidative and ER stress in cardiomyocytes.
• Validating preclinical models for cardioprotective drug discovery based on the described H9C2 cell and mouse model protocols.

Strengths

• The underlying study employs multiple validation methods, including SIRT1 knockdown/knockout models, to verify mechanistic necessity.
• Data is shared under a permissive CC-BY-4.0 license, allowing for broad reuse and redistribution.
• The description provides a detailed methodological overview of the in vitro and in vivo experiments conducted.

Limitations

• The dataset is a 845.7 KB DOCX file, which is a small supplementary document rather than a primary data repository.
• Row count and column-level documentation are absent; data structure and semantics must be inferred from the text.
• Description metadata is limited; actual data quality and completeness require manual inspection after download.

Provenance

Source

figshare

Collection Method

Data likely generated from laboratory experiments on H9C2 cardiomyocytes and mouse models, as described.

Freshness

Last updated 2026-04-23 05:27:31; freshness should be verified.