TCR Repertoire Data Across Human Ontogeny

Umbilical cord blood TCRβ repertoire data from naïve T cell subsets across developmental stages, including early gestation (24–29 weeks), term, neonates, children, adults, and older individuals. The dataset characterizes features like CDR3 region length, repertoire convergence, and public clonotype abundance. It was authored by Mikhail Yu. Myshkin and shared under a CC BY 4.0 license.

Use Cases

• Analyze CDR3 region length differences between umbilical cord blood and adult TCRβ repertoires.
• Track changes in repertoire convergence and public clonotype abundance across age groups from neonates to older individuals.
• Compare TCRβ repertoire features, such as TRBV gene usage, between naïve CD4+, naïve CD8+, and naïve regulatory T cell subsets.
• Investigate the predicted binding strength of CDR2 in repertoires of naïve Treg and naïve CD8+ T cells across developmental stages.

Strengths

• Covers multiple developmental stages from early gestation (24–29 weeks) through older age.
• Includes data from three distinct naïve T cell subsets: CD4+, CD8+, and regulatory T cells.
• Shared under a permissive CC BY 4.0 license for reuse.

Limitations

• Dataset size is small at 12.8 MB, suggesting limited data volume.
• Data is provided in a DOCX file format, which is not ideal for direct computational analysis.
• Specific row and column counts are unknown, complicating assessment of dataset scale and structure.

Provenance

Source

figshare

Collection Method

TCRβ repertoire analysis from sorted naïve T cell subsets from blood samples.

Time Range

Developmental stages from 24–29 weeks gestation through older age.

Freshness

Last updated March 2026.

Geography

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