Supplementary Data for Tectochrysin's Effect on Ang II-Induced Cardiac Hypertrophy

Supplementary file 1 from a study investigating the flavonoid Tectochrysin as a potential treatment for pathological cardiac hypertrophy. The 30.8 MB document, authored by Yanghao Chen and last updated in April 2026, contains supporting data for experiments using an Angiotensin II-induced mouse model and in vitro cardiomyocyte assays. Research methods include echocardiography, histopathology, transcriptome sequencing, and molecular interaction assays to identify STING as the compound's target.

Use Cases

• Validate anti-hypertrophic drug mechanisms based on described STING/NFκB pathway inhibition data.
• Correlate transcriptomic sequencing results with histological and echocardiographic outcomes mentioned in the study.
• Compare molecular binding assay results (DARTS, CETSA, SPR) for flavonoid compounds targeting STING.

Strengths

• Data is associated with a detailed mechanistic study published on figshare.
• The dataset is shared under a permissive CC-BY-4.0 license, allowing reuse with attribution.

Limitations

• The dataset is a single 30.8 MB DOCX file; data structure and column definitions are unknown.
• Row count and the specific format of embedded data (e.g., tables, figures) are not specified.
• Freshness should be verified; the last update date is 2026-04-23, which is in the future relative to the current date.

Provenance

Source

figshare, authored by Yanghao Chen.

Collection Method

Data generated from in vivo mouse models and in vitro cell studies, as described in the accompanying research.

Freshness

Last updated 2026-04-23 05:34:52