Antipsychotic Use in Dementia: Mortality and Adverse Event Meta-Analysis, 2010-2024

A systematic review and meta-analysis synthesizing evidence on antipsychotic drug consequences for people living with dementia. The analysis includes 45 studies with approximately two million participants, published between January 2010 and August 2024. The work was authored by Poe Eindra Thant and registered with PROSPERO (CRD42022312570).

Use Cases

• Assessing mortality risk associated with antipsychotic use based on pooled hazard ratios from 25 studies.
• Comparing adverse outcomes like stroke or pneumonia risk between typical and atypical antipsychotics based on subgroup analyses.
• Evaluating the certainty of evidence for clinical guidelines using the GRADE framework described in the review.

Strengths

• Follows PRISMA guidelines and includes a registered protocol (CRD42022312570).
• Meta-analysis pools data from 45 studies covering approximately two million participants.
• Includes subgroup analyses by drug type, study design, and patient setting.

Limitations

• The primary file is a 2.2 MB DOCX document; data extraction for computational analysis would be required.
• Evidence for non-fatal adverse outcomes like stroke or fractures is described as limited and heterogeneous.
• Row count and column-level documentation for any underlying data are unknown.

Provenance

Source

figshare

Collection Method

Systematic literature review of PubMed, EMBASE, Cochrane Library, and Web of Science.

Time Range

Studies published between January 2010 and August 2024.

Freshness

Last updated 2026-05-08 05:53:38.