Supplementary file 1_The impact of CSF1R inhibitor-mediated microglial depletion in rodent

Ana Flavia F. Ferreira's systematic review and meta-analysis evaluates the effects of microglial depletion using CSF1R inhibitors like PLX3397 and PLX5622 in preclinical models of Alzheimer's and Parkinson's disease. The work synthesizes results from 26 Alzheimer's disease and 17 Parkinson's disease studies. It was last updated on March 17, 2026, and is shared under a CC-BY-4.0 license.

Use Cases

• Meta-analysis of neuroprotective effects based on reported outcomes from 43 preclinical studies
• Comparative analysis of intervention timing based on the described gap in post-onset studies
• Synthesis of behavioral and pathological endpoints based on the review's contradictory and variable findings

Strengths

• The review synthesizes a defined corpus of 43 preclinical studies (26 AD, 17 PD).
• It includes a formal systematic review registration (CRD420251075163).
• The analysis distinguishes between disease models and specific depletion protocols like PLX3397 and PLX5622.

Limitations

• The dataset is a 12.8 KB DOCX file, indicating a very small-scale textual summary rather than raw experimental data.
• Column-level documentation is absent; field semantics must be inferred after download.
• The description notes high heterogeneity and variability among the included studies as a clear limitation.

Provenance

Source

Ana Flavia F. Ferreira via figshare

Collection Method

Systematic review and meta-analysis of published preclinical studies.

Time Range

Temporal coverage of the included studies is not specified.

Freshness

Last updated 2026-03-17 13:04:54; freshness should be verified.

Geography

Spatial coverage is not specified.