Saliva and Serum Biomarkers Linked to Alveolar Bone Deterioration in Periodontitis

Biomarker data from a periodontitis model study identifies key inflammatory factors correlated with bone destruction. The dataset includes Micro-CT bone parameters and multiplex liquid chip assay results for 21 biomarkers in saliva and serum. Author Yawen Cui published this supplementary file on figshare in May 2026.

Use Cases

• Identifying key inflammatory biomarkers for periodontitis based on XGBoost feature importance scores.
• Correlating saliva and serum biomarker levels with alveolar bone microstructural parameters like BV/TV and Tb.Sp.
• Investigating the role of pyroptosis-related proteins (e.g., GSDMD) in periodontal bone destruction.

Strengths

• Multimodal data includes Micro-CT bone measurements and 21 biomarker assays from two biofluids.
• Analysis identifies specific key biomarkers (MCP-1, TNF-α, CASP-1) with quantified contributions (e.g., MCP-1 at 67.7% in serum).
• Findings are validated with multiple linear regression, correlation tests, and histological assessment.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data scale is limited to a single animal model study (937.4 KB file).

Provenance

Source

figshare

Collection Method

Data generated from a maxillary molar ligation periodontitis model in rodents.

Freshness

Last updated 2026-05-13 04:29:51; freshness should be verified.