CALLY Index Prognostic Value in Sepsis: A Systematic Review and Meta-Analysis

A meta-analysis of six studies encompassing 3,848 patients with sepsis, investigating the C-reactive protein-albumin-lymphocyte (CALLY) index as a prognostic biomarker. The analysis was conducted by Chuangying Xie and published on figshare in May 2026. It pools data from Chinese and Turkish cohorts to assess the index's association with mortality risk.

Use Cases

• Validating a composite biomarker for sepsis mortality prediction based on inflammation, nutrition, and immunity metrics.
• Assessing heterogeneity in biomarker performance across different ethnic cohorts, as indicated by subgroup analyses.
• Benchmarking the diagnostic accuracy of a low-cost biomarker using pooled sensitivity and specificity metrics from the meta-analysis.
• Informing the design of large, multinational prospective studies for biomarker validation, as suggested by the conclusion.

Strengths

• Includes pooled results from 3,848 patient records across seven cohorts.
• Provides specific statistical metrics: pooled SMD of -0.22, HR of 0.48, sensitivity of 0.59, and specificity of 0.77.
• Released under a permissive CC-BY-4.0 license, facilitating reuse.
• Systematic review protocol is registered with identifier INPLASY2025120023.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Significant heterogeneity was observed across all pooled analyses, as noted in the results.

Provenance

Source

figshare, authored by Chuangying Xie.

Collection Method

Systematic review and meta-analysis of studies from PubMed, Embase, OVID, Web of Science, CNKI, Wanfang, Google Scholar, and Baidu Scholar.

Time Range

Literature search conducted up to November 15, 2025.

Freshness

Last updated 2026-05-08 05:51:50; freshness should be verified.

Geography

Studies include Chinese and Turkish patient cohorts.