Supplementary file 1_The pterocarpan (+)-PTC modulates cytoskeletal proteins and induces a

212 differentially expressed proteins were identified in PC-3 prostate cancer cells treated with the pterocarpan (+)-PTC. The dataset includes quantitative LC-MS/MS proteomic profiles from cells treated with two concentrations of (+)-PTC and comparator drugs nocodazole and monastrol. Author José de Brito Vieira Neto published the data on figshare in June 2026 under a CC-BY-4.0 license.

Use Cases

• Identify protein biomarkers of drug response based on the list of 212 differentially expressed proteins.
• Compare mechanisms of action between different microtubule-targeting agents based on proteomic overlap with nocodazole and monastrol treatments.
• Investigate pathways linking cytoskeletal dynamics to apoptosis based on the upregulation of proteins like TTLL3 and ANAPC7 and downregulation of KDM2B and PTOV1.

Strengths

• Includes quantitative proteomic data for 212 differentially expressed proteins.
• Provides comparator data from established drugs (nocodazole, monastrol) for mechanism analysis.
• Apoptosis and mitochondrial depolarization results are validated by flow cytometry and caspase assays.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is a 4.3 MB DOCX file, which may require extraction of underlying data tables.

Provenance

Source

figshare

Collection Method

Global proteomic profiling performed by quantitative LC-MS/MS using a 2D nano-UPLC data-independent acquisition platform on treated PC-3 cells.

Freshness

Last updated 2026-06-03 06:04:49; freshness should be verified.