Meta-Analysis of Vitamin D Supplementation on Inflammation in Hemodialysis Patients

A 2025 meta-analysis by Chen Li aggregates results from eight randomized controlled trials involving 617 maintenance hemodialysis patients. The study examines the effect of nutritional vitamin D supplementation on biomarkers like CRP, serum albumin, TNF-α, and iPTH. The analysis was conducted using RevMan 5.4 and Stata 17, with results published on figshare in 2026.

Use Cases

• Analyzing the effect of vitamin D on inflammatory markers like CRP and TNF-α based on the meta-analysis results
• Evaluating the safety profile of vitamin D supplementation based on reported adverse events, hypercalcemia, and hyperphosphatemia
• Comparing changes in nutritional status based on serum albumin levels between intervention and control groups
• Assessing the impact on bone metabolism based on changes in immunoreactive Parathyroid Hormone (iPTH) levels

Strengths

• Aggregates data from eight randomized controlled trials, a common standard for clinical evidence
• Includes results for 617 patients, providing a pooled sample size
• Reports specific statistical outcomes, such as a mean difference of -3.15 for CRP reduction with 95% confidence intervals

Limitations

• The dataset is a 2.0 MB DOCX file; the underlying data tables are not provided in a structured, machine-readable format
• Column-level documentation is absent; field semantics must be inferred from the text
• Row count for the original trial data is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Meta-analysis of published randomized controlled trials.

Time Range

Studies published up to March 1, 2025 were included.

Freshness

Last updated 2026-05-29 06:11:37