Fluvoxamine Effects on LPS-Induced Acute Lung Injury in Mouse Model

Fluvoxamine, an antidepressant, mitigated LPS-induced pulmonary inflammation and functional deterioration in wild-type mice via sigma-1 receptor signaling. The dataset is a 66.8 KB DOCX file containing supplementary information for a study comparing fluvoxamine and dexamethasone treatments in wild-type and S1R knockout mice. Author Emese Ritter uploaded it to figshare under a CC-BY-4.0 license, with a last update timestamp of 2026-04-28.

Use Cases

• Compare the anti-inflammatory efficacy of fluvoxamine versus dexamethasone based on the described mouse model results.
• Investigate the role of sigma-1 receptor signaling in lung injury based on genotype-specific response data.
• Analyze the impact of LPS on respiratory parameters like tidal volume and minute ventilation mentioned in the results.
• Study the modulation of specific inflammatory cytokines (IL-1, IL-6, TNF-α, MCP-1) by pharmacological intervention.

Strengths

• The study design includes a clear comparison between wild-type and S1R knockout mice, allowing for mechanistic inference.
• Specific dosages (LPS 0.5 mg/kg, FLU 20 mg/kg, dexamethasone 5 mg/kg) and treatment groups are detailed in the methods.
• The dataset is shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• The dataset is a 66.8 KB DOCX file, suggesting limited scope and likely containing textual results rather than raw experimental data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare

Collection Method

Likely contains supplementary data and text from a controlled laboratory experiment inducing pneumonitis in mice.

Freshness

Last updated 2026-04-28 05:27:32; freshness should be verified.