BVDV Antibody Efficacy Data in Mouse Challenge Model

A PDF document details experimental results on bovine ultra-long CDR H3 antibodies against Bovine Viral Diarrhea Virus (BVDV). The study reports in vitro antibody affinity of 312.5 ng/mL, neutralizing activity with an IC50 of 11.72 μg/mL, and in vivo results from a BALB/c mouse challenge model. Authored by Gege Rile and uploaded to figshare in April 2026.

Use Cases

• Analyze the reported antibody affinity (312.5 ng/mL) and neutralizing activity (IC50 = 11.72 μg/mL) for benchmarking novel BVDV therapeutics.
• Compare viral load reduction and histopathological damage attenuation between treated and control groups in the BALB/c mouse model data.
• Study the construction and biopanning results of the phage display library encoding BVDV-specific ultralong CDR H3 antibodies.
• Evaluate the statistical significance (P < 0.05) of therapeutic efficacy findings for validating the antibody platform.

Strengths

• Reports specific quantitative metrics: antibody affinity of 312.5 ng/mL and IC50 of 11.72 μg/mL.
• Includes in vivo challenge model results with statistical significance (P < 0.05).
• Published under a permissive CC-BY-4.0 license for reuse.

Limitations

• Dataset is a single 265.2 KB PDF file, containing summarized results rather than raw experimental data tables.
• No raw columnar data, sample data, or row counts are provided, limiting computational analysis.
• Geographic origin of the study or sample source is not specified.

Provenance

Source

figshare, authored by Gege Rile.

Collection Method

Experimental research involving phage display library construction, biopanning, antibody expression/purification, and mouse challenge model.

Time Range

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Freshness

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Geography

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