Zebrafish Transcriptomic Data on Tanshinone IIA Effects for Osteoporosis

RNA sequencing data from a zebrafish model identifies 505 genes with reversed expression profiles after Tanshinone IIA treatment for glucocorticoid-induced osteoporosis. The dataset includes results from alizarin red S, calcein, and alcian blue staining to assess bone and cartilage development. Author Xinyu Li published the data on figshare under a CC-BY-4.0 license.

Use Cases

• Identify differentially expressed genes in skeletal development based on RNA sequencing results.
• Analyze protein-protein interaction networks to elucidate gene associations mentioned in the description.
• Validate therapeutic effects on bone mineralization and density using staining assay data.
• Investigate key signaling pathways like PPAR signaling and lipid metabolism implicated in the study.

Strengths

• Includes transcriptomic analysis of 505 genes with reversed expression profiles.
• Validation performed via quantitative reverse transcription polymerase chain reaction.
• Data from multiple experimental methods: alizarin red S, calcein, and alcian blue staining.

Limitations

• Dataset is small at 839.8 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Experimental data from zebrafish larvae studies, including RNA sequencing and histological staining.

Freshness

Last updated 2026-03-18 06:42:29.