Tongxie Yaofang IBS-D Study: Gut Microbiota and Metabolite Analysis in a Rat Model

A 2026 study by Xiangyu Xie investigating the effects of the traditional Chinese medicine Tongxie Yaofang on Irritable Bowel Syndrome with Diarrhea (IBS-D) in a rat model. The research includes data from 16S rRNA sequencing, untargeted metabolomics, and fecal microbiota transplantation experiments. The dataset is a supplementary document describing the study's methods and results.

Use Cases

• Analyzing the relationship between Bifidobacterium abundance and IBS-D symptom alleviation based on the study's findings.
• Investigating the microbial conversion of tryptophan to metabolites like 5-HIAA and IAA as described in the results.
• Studying the activation of the aryl hydrocarbon receptor (AhR) signaling pathway in the context of intestinal barrier function restoration.
• Validating therapeutic mechanisms via fecal microbiota transplantation (FMT) data referenced in the methodology.

Strengths

• Study employs multiple validation methods including 16S rRNA sequencing, untargeted metabolomics, and fecal microbiota transplantation.
• Mechanistic pathway from gut microbiota to AhR signaling and barrier function is explicitly described in the results.
• Dataset is openly licensed under CC-BY-4.0, permitting reuse and redistribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a 289.4 KB DOCX document, which may require extraction or conversion for computational analysis.

Provenance

Source

figshare, authored by Xiangyu Xie.

Collection Method

Data generated from a laboratory study using an IBS-D rat model, HPLC, sequencing, and metabolomics.

Time Range

Study dated 2026.

Freshness

Last updated 2026-04 30 12:24:34; freshness should be verified.

Geography

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