Clinical Case Report on Toxicity-Guided Antimicrobial Dose Modification

A single clinical case report details the pharmacological management of a 55-year-old male gold miner with pneumoconiosis and disseminated Nocardia farcinica brain abscess. The report, authored by Hui Juan Liu and published on figshare in April 2026, describes diagnosis via metagenomic next-generation sequencing (mNGS) and an individualized antimicrobial regimen based on toxicity monitoring.

Use Cases

• Analyze clinical outcomes based on toxicity-guided dose modification described in the report
• Study diagnostic methods for disseminated nocardiosis based on the use of metagenomic next-generation sequencing (mNGS)
• Review pharmacological management strategies based on the combination therapy with imipenem, amikacin, and TMP-SMX
• Investigate dose-limiting toxicity scenarios based on the reported grade III gastrointestinal toxicity (CTCAE v5.0)

Strengths

• Report includes specific drug dosing details (e.g., TMP-SMX de-escalated from 15 mg·kg−1·d−1 to 11.25 mg·kg−1·d−1)
• Case details include patient demographics (55-year-old male gold miner with pneumoconiosis) and clinical timeline (Day 120)
• Diagnostic method (metagenomic next-generation sequencing) and pathogen (Nocardia farcinica) are explicitly identified

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data may reflect bias inherent to a single case report from figshare

Provenance

Source

Hui Juan Liu

Collection Method

Observational case study

Freshness

Last updated 2026-04-09 04:06:35; freshness should be verified