Transcriptomic Profiling of Chlorogenic Acid and Taurine in Human Skin Cells

Encompassing transcriptomic RNA sequencing data profiling gene expression changes in human epidermal keratinocytes, melanocytes, and fibroblasts following treatment with chlorogenic acid, taurine, or their combination. It identifies 197 differentially expressed genes (DEGs), of which 62 were prioritized as aging-related DEGs (AR-DEGs). The data provides molecular insights into cellular senescence mechanisms and potential anti-aging strategies.

Use Cases

• Identify aging-related differentially expressed genes (AR-DEGs) like FST from the 62 prioritized candidates for association with skin aging phenotypes.
• Analyze synergistic gene expression responses in human keratinocytes, melanocytes, and fibroblasts following co-treatment with chlorogenic acid and taurine.
• Validate representative genes identified in the transcriptome-wide RNA sequencing using quantitative real-time PCR data.
• Investigate regulatory transcription factors such as TGFB2, ETS1, and EGR1 highlighted in anti-senescence-associated pathways.

Strengths

• Identifies 197 differentially expressed genes (DEGs) from transcriptome-wide RNA sequencing.
• Prioritizes 62 aging-related DEGs (AR-DEGs) based on integration with aging databases and pathway enrichment.
• Profiles gene expression across three human skin cell types: keratinocytes, melanocytes, and fibroblasts.

Limitations

• Data is provided as a 6.7 MB PDF, limiting direct computational analysis and requiring text/data extraction.
• The sample size and number of biological replicates for the RNA sequencing experiments are not specified.
• No raw sequencing data or processed data tables are directly available as a structured file.

Provenance

Source

figshare, author Beomsu Kim.

Collection Method

Transcriptome-wide RNA sequencing on human skin cells treated with compounds, integrated with evidence from aging databases and GWAS.

Freshness

Last updated March 20, 2026.